Future research should focus on illuminating how different interstitial lung disease subtypes affect outcomes in AAV. Interstitial lung disease (ILD) patterns differ between patients with ...

Serum CXCL6 was higher in ANCA-associated vasculitis with interstitial lung disease and independently predicted ILD progression, suggesting a blood biomarker to identify AAV-ILD and monitor risk.

For gene therapy to work well, therapeutic molecules need to be efficiently delivered to the correct locations in the body -- a job commonly given to adeno-associated viruses (AAV). To improve the AAV ...

CLEVELAND, June 17, 2024 (GLOBE NEWSWIRE) -- NovelMed proudly announces the U.S. Food and Drug Administration's (FDA) clearance on Ruxoprubart, the investigational drug, for commencing an efficacy ...

Alveolar macrophages are immune cells that live in the tiny air sacs of the lungs. Under normal conditions, these cells act ...

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a severe autoimmune condition in which circulating autoantibodies target components of neutrophils, notably proteinase 3 and ...

-Interim results from Phase II AAVIATE and ALTITUDE trials of dose level 3 cohorts with short-course prophylactic steroid eye drops resulted in zero cases of intraocular inflammation -Initial safety ...

The direct immunologic role of CD200 and CD200R in AAV pathogenesis is still unclear. However, the researchers suggest that increased inflammation during active disease may increase CD200 expression, ...

* Scientists engineered a way to deliver genes directly to lung and airway cells using a nasal spray * AAV.CCP.16 -// a viral vector outperformed older tools like AAV6 and AAV9, offering a safer, ...

Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection. Infection with the influenza virus ...