Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein. A member of the RNA-associated ...

Solving the structure of an amyloid protein gives new insight into limb-girdle muscular dystrophy type 3 (LGMD D3) and functional protein aggregation. LGMD D3 is a rare disease characterized by slow ...

Openwater has developed a low-intensity focused ultrasound device that might one day noninvasively disrupt microclots in long ...

Super-resolution microscopes have revealed a whole new type of connection between neurons in mouse and human brains. In the ...

For decades, the structures of repetitive, flexible folds of amyloid fibrils eluded X-ray crystallographers, but with the advent of cryo-electron microscopy, these elusive amyloids were no longer able ...

This is a preview. Log in through your library . Abstract Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level polymorphisms that may contribute to variations in clinical and pathological ...

(Boston)—Alzheimer’s disease (AD) is a debilitating incurable disease that affects millions of patients worldwide. Deposits of amyloid beta (Aβ) amyloid in the brain is key to AD pathology at early ...

The pursuit of a cure for Alzheimer's disease is becoming an increasingly competitive and contentious quest, with recent ...

Devastating neurodegenerative diseases like Huntington's, Alzheimer's, and Parkinson's are all associated with protein deposits in the brain, known as amyloid. Despite extensive research investment ...

Alzheimer’s disease is characterized by certain key changes in the brain. Among them are the development of two kinds of ...