Cystic fibrosis (CF) is a genetic condition that affects the lungs, pancreas and other organs, caused by variations on the cystic fibrosis transmembrane conductance regulator  (CFTR) gene. There are ...

Protein misfolding is a common feature of genetic diseases such as cystic fibrosis and phenylketonuria (PKU). For these diseases, compounds that aid the folding and/or increase the native-state ...

The CFTR Protein Distribution Core offers high-quality, full-length recombinant cystic fibrosis transmembrane conductance regulator (CFTR) proteins expressed in and purified from mammalian cells. Wild ...

Get it wrong with your laundry and the result can be a crumpled, wrinkled mess of fabric, but when folding fails among the approximately 7,000 proteins ... emphysema and cystic fibrosis to ...

supporting the hypothesis that ER overload contributes to the chronic inflammation that often contributes to the high morbidity in cystic fibrosis. The `unfolded-protein response' triggered by the ...

Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the CFTR gene that causes the protein to ...

The genetic disorder cystic fibrosis ... as the cystic fibrosis transmembrane conductance regulator (CFTR), says Basavaraj. He explains that these mutations eventually cause a protein imbalance ...

Cystic fibrosis is caused by hereditary genetic mutations that impair or halt the production of the CFTR protein. The respiratory tract is most severely affected. There, the mucus becomes so ...