The Th1 cytokines, as well as cytotoxic CD8 + T cells, may promote macrophage/microglial activity, which in turn translates into loss of the oligodendrocyte/myelin complex. Multiple sclerosis (MS ...

More information: Rui Li et al, Oxidative phosphorylation regulates B cell effector cytokines and promotes inflammation in multiple sclerosis, Science Immunology (2024). DOI: 10.1126/sciimmunol ...

is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal ...

In 2006, six healthy young men were left in intensive care with multiple organ failure as a result of an out-of-control cytokine immune response during a preclinical trial of a new kind of drug.

Findings show accumulation of neuronal injury and functional decline suggesting that changes in gonadal hormones may be associated with changes in functional and biological markers in MS.

The interleukin-17 (IL-17) family cytokines are strong inducers of ... rheumatoid arthritis and multiple sclerosis. The landmark discovery that IL-17-producing T cells were central drivers of ...