The Kyle Shanahan era in San Francisco is defined not only by success, but by survival. Since he arrived as head coach in ...

The San Francisco 49ers have had some bad luck with injuries in their front seven, and they may have lost another defender against the Houston Texans.

The San Francisco 49ers have already lost linebacker Fred Warner to a long-term injury, and now they may have lost another player at the position.

The San Francisco 49ers need edge rusher help and that has led one analyst to predict the team will make a big trade for ...

The San Francisco 49ers got Alfred Collins back late in the second quarter against the Texans and almost immediately lost ...

The San Francisco 49ers have a big decision looming ahead of the Nov. 4 NFL trade deadline after key injuries.

The San Francisco 49ers have now played two full games with Nick Bosa, two full games without Nick Bosa, and one game in which he started and left early. The 49ers are 2-0 with Bosa and 1-1 without ...

The are an impressive 4-1 heading into Week 6. It's an impressive accomplishment since they've been missing a lot of players due to injury. George Kittle, Brock Purdy, Ricky Pearsall, and Jauan ...

Okuayinonu is questionable to return to Sunday's matchup against Houston due to an ankle injury, Nick Wagoner of ESPN.com reports. Okuayinonu was injured on a C.J. Stroud scramble early in the fourth ...

The San Francisco 49ers need a big Thursday night win over the Los Angeles Rams to stay afloat in the early NFC West division race. Unfortunately, they'll have to do so without starting quarterback ...

It didn't take long for the San Francisco 49ers to miss superstar defensive end Nick Bosa. The impact of his absence due to a torn ACL he suffered in Week 3 was felt immediately in the 49ers' Week 4 ...