Diabetic neuropathy affects a large proportion of individuals with long-term diabetes and may often go unnoticed in the early stages of the condition.

Decades of research elucidating the pathophysiology of diabetic neuropathy have failed, thus far, to produce a treatment that prevents or reverses its development and progression. Recently ...

Diabetic neuropathy also may simulate tumors or degenerative diseases of the nervous system or malignancy of the gastrointestinal tract.

A diagnosis of diabetic peripheral neuropathy can be confirmed after electrodiagnostic, sensory, and autonomic function testing.

The pathogenesis of diabetic neuropathy is complex and is marked by both metabolic and vascular factors including hyperglycemia, toxic adiposity, oxidative stress, mitochondrial dysfunction ...

Two frequent features of diabetes are peripheral vascular disease leading to ischaemic lower limb extremities, and sensory neuropathy, which renders the patient prone to foot injury and vulnerable to ...

Finding that altered serine metabolism in diabetes leads to peripheral neuropathy may provide a way to identify people at high risk, and a potential treatment option.

Pathophysiology of Diabetic Neuropathy Recent studies in patients with impaired glucose tolerance provide important insights into the role of the degree of glucose dysmetabolism in the development ...

Painful peripheral neuropathy is common among patients with diabetes mellitus. Management includes lifestyle interventions and pharmacologic therapy to control cardiovascular risk factors and medic ...