Purdue University researchers have taken the first steps to treat Alzheimer’s disease, Parkinson’s disease and Type 2 diabetes by creating multiple patent-pending compounds shown to inhibit protein ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

A designer version of the tau protein, developed by a team led by UT Southwestern Medical Center researchers, maintains its ...

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are ...

Researchers headed by a team at the Centre for Genomic Regulation, Barcelona Institute of Science and Technology and at the Wellcome Sanger Institute have developed an AI tool that they say has made a ...

Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now used new in vitro and ...

yTRAP can be used to create cellular sensors for protein aggregation. The sensor produces fluorescent signals that depend on the protein aggregation state in the cell. In this experiment, three cell ...

The aging brains of people with Alzheimer’s, Parkinson’s and other neurodegenerative diseases are suffused with telltale aggregates of proteins in or around their neurons. How these protein clumps ...

Researchers dissolved human insulin (Sigma I2643) in acidified deionized water to concentrations of 2 mg/mL. After they had dissolved, the pH was adjusted with 0.1 M HCl and 0.1 NaOH to pH 4.3. All ...

Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases. To overcome these limitations, scientists developed the real-time quaking-induced ...