A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...
The mechanical environment of smooth muscle cells and the surrounding extracellular matrix orchestrates vascular tone, tissue remodelling and pathology. Smooth muscle cells reside within a fibrous ...
DHA has previously been shown to inhibit voltage-dependent Ca 2+ channels (VDCCs). The research group found a new pharmacological action of DHA to inhibit the Orai1 channel, which is one of ...
Because RyR1 is also expressed in neurons, immune cells, and vascular smooth muscle, the E3896A model offers a unique tool to examine CICR's broader physiological roles. By combining gene engineering, ...
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