Carbonic anhydrase inhibitors (CAIs) have long represented a versatile class of agents in clinical medicine. By targeting the zinc metalloenzymes responsible for rapidly converting carbon dioxide to ...

• Carbonic anhydrases (CAs) are involved in CO₂ uptake and conversion, a fundamental process in photosynthetic organisms. Nevertheless, the mechanism underlying the regulation of CO₂ uptake and ...

This is a preview. Log in through your library . Abstract External carbonic anhydrase (CA) was detected in whole cells of alkaline-grown Chlorella saccharophila but was suppressed by growth at acid pH ...

Researchers have discovered a new group of carbonic anhydrase enzymes that do not require any metal ions for their activity, which improves our knowledge of the global carbon cycle and may be ...

Mesothelioma is an aggressive tumor with a poor prognosis. Histological diagnosis of mesothelioma using limited tissue samples can be challenging. Carbonic anhydrase IX (CAIX) is a transmembrane ...

Carbonic anhydrase IX (CAIX) is overexpressed in the hypoxic tumor environment and is thought to help drive tumor progression and metastasis by generating protons that acidify the area. Therefore, ...

In a recent study published in Nature Chemical Biology, University of Cambridge scientists used zebrafish models of tauopathies — a group of neurodegenerative diseases driven by tau protein ...

(a) Hematoxylin and eosin (H&E) stain (100×) on a needle biopsy specimen showing clusters of epithelioid tumor cells in a fibrotic stroma. (b) Corresponding area to (a) with positive nuclear and ...

A new study describes a significant step toward improving photosynthesis and increasing yields by putting elements from cyanobacteria into crop plants. In order to feed a projected 9 billion people by ...

(Philadelphia, PA) – Changes in blood vessels in the brain linked to the build-up of a sticky protein known as amyloid beta are a hallmark of early-stage Alzheimer’s disease. As amyloid accumulates on ...