Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their ...
A novel Raman technique measures protein–ligand binding at physiologically relevant conditions in real time. Researchers at the Texas Agricultural and Mechanical University (TX, USA) have developed a ...
Recently, SandboxAQ launched what it claims is the largest publicly available dataset of protein-ligand pairs with annotated experimental binding potency data. According to the company, the ...
Since it pre-accounts for critical factors in protein-ligand binding, it has a much higher likelihood of generating effective and stable molecules. The generation process visually demonstrates how ...
Scientists have revealed the effect of temperature on water in protein-ligand interactions, providing a way to produce structures for drug discovery that are less biased by freezing artifacts.
In a recent study published in Molecular Systems Biology, researchers demonstrated that advances in modeling protein-ligand interactions using machine learning-based approaches are needed to exploit ...
Researchers say findings could lead to breakthroughs in tissue repair and regenerative medicine, as well as advanced medical ...
We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to human FAP with ...
From its perch on the cell surface, low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) somehow manages to nab ligands, bring them to the endosome, drop them off, and return to the cell ...
(Memphis, Tenn.—June 7, 2022) Cryogenic (frozen) protein structures are central to understanding function and developing drugs. Scientists at St. Jude Children’s Research Hospital have created an ...
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