Both the Boston Celtics and Cleveland Cavaliers may be without multiple key players in Wednesday night's matchup.

The Cleveland Cavaliers face the Boston Celtics in a regular season NBA game on Wednesday, Oct. 29, 2025 (10/29/25) at TD Garden in Boston, Mass.

Donovan Mitchell scored 35 points in just 29 minutes, and the Cleveland Cavaliers beat the Detroit Pistons 116-95 on Monday night for their third straight victory.

On Wednesday, Mitchell was added to the team’s growing list of injuries. The Cavaliers announced their official injury report to the NBA ahead of Wednesday’s game against the Boston Celtics, and Mitchell’s name appeared just hours before tipoff. He was listed as questionable with left hamstring tightness.

Here is the latest news about Jaylen Brown's status ahead of the Celtics' 7 p.m. tip-off against the Cavaliers

Donovan Mitchell scored 24 points, including 10 in the fourth quarter, as the Cleveland Cavaliers held off the Milwaukee Bucks to win their home opener 118-113.

After losing their season opener to the New York Knicks, the Cleveland Cavaliers rattled off three wins in four days, including a back-to-back sweep against the

During the Cleveland Cavaliers ' season opener at Madison Square Garden, guard Lonzo Ball hit big man Larry Nance Jr. with a perfectly placed lob pass. Nance threw it down, punctuating a 10-0 Cavs run and prompting sidelined star Darius Garland to rise from his seat and let out a scream that was clearly audible on the ESPN broadcast.