Scientists have pinpointed precise regions in the human genome where DNA is most likely to develop a mutation.

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing ...

PURPOSE: Reverse transcriptase (RT) polymerase chain reaction (PCR) with multiple markers has been demonstrated to be highly sensitive in detecting circulating cells from patients with malignant ...

As expected, accuracy also depended on whether the DNA polymerase retains a 'proofreading' functionality, which verifies (and if necessary removes) any mismatched nucleotides: a version of the enzyme ...

This is a preview. Log in through your library . Abstract Two general models have been proposed for DNA replication. In one model, DNA polymerase moves along the DNA (like a train on a track); in the ...

The Caenorhabditis elegans germ-line development defective (GLD)-2–GLD-3 complex up-regulates the expression of genes required for meiotic progression. GLD-2–GLD-3 acts by extending the short poly(A) ...

Constitutional WT1 mutations in Wilms' tumor patients. Ninety-five percent of children with acute lymphoblastic leukemia (ALL) will achieve a remission, but approximately 25% will relapse. Identifying ...

Finnzymes has launched a novel hot start DNA polymerase that outperforms every Taq-based hot start polymerase on the market. Phire Hot Start DNA Polymerase incorporates a DNA-binding domain, a design ...

Prokaryotes contain five different types of DNA polymerase. These are described below. Polymerase I is a DNA repair enzyme from the family A polymerases that has a 5’ to 3’ and 3’ to 5’ activity. Pol ...

Polymerase chain reaction was found to be more sensitive than culture in detecting fungal keratitis, and results were obtained in only 4 to 8 hours. Culture for detecting mycotic keratitis has been ...