We have developed adenoviral vectors with a prostate-specific two-step transcriptional amplification (TSTA) system that would express therapeutic genes at a robust level to target metastatic disease.

Also, the vectors are customizable and could potentially be used as part of a gene therapy to treat neurodegenerative disorders that affect the entire central nervous system, such as Huntington's ...

In addition, some studies have reported different distribution profiles of viral vectors in the central auditory system after a cochlear inoculation.

Andrew J. Bett, Wael Haddara, Ludvik Prevec, Frank L. Graham, An Efficient and Flexible System for Construction of Adenovirus Vectors with Insertions or Deletions in Early Regions 1 and 3, Proceedings ...