Gut

SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL

Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in ...
Gut

Congenital sucrase-isomaltase mutations worsen IBS-linked V15F dysfunction and trafficking

Several seminal studies published in Gut have demonstrated a strong association between dysfunctional sucrase-isomaltase (SI) ...
Gut

Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort

Early broadly neutralising antibody responses against the E1E2 glycoprotein seem to be important for preventing persistence ...
gut.bmj

PDE5A + cancer-associated fibroblasts enhance immune suppression in gastric cancer

Background Gastric cancer (GC) ranks among the most prevalent lethal tumours globally. Cancer-associated fibroblasts (CAFs) are pivotal in creating an immunosuppressive tumour microenvironment (TME) ...
gut.bmj

DPP-4 inhibitor alleviates gut-brain axis pathology in Parkinson’s disease

5 Catholic Kwandong University College of Medicine Department of Medical Science, Gangneung-si, The Republic of Korea Background Dipeptidyl peptidase-4 inhibitors (DPP-4is) have been reported to ...
gut.bmj

Response to: Cutting waste in endoscopy: the roles of professional practice and staffing levels by Fujisawa and Fujikawa

We thank Drs Fujisawa and Fujikawa for their thoughtful comments, which highlight professional and organisational determinants that complement our data on waste generation.1 2 In our multicentre study ...
gut.bmj

Response to: ‘Lumen-apposing metal stents for pancreatic fluid collections: has advancing technology encouraged overreach?’ by Besim Fazil et al

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites ...
gut.bmj

Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation

Section of Digestive Diseases and Nutrition, University of Illinois at Chicago and Chicago Veterans Administration Medical Center (West Side Division), Chicago, IL, USA Correspondence to: Dr G Hecht, ...
gut.bmj

High risk of hepatocellular carcinoma and death in patients with immune-tolerant-phase chronic hepatitis B

Objective High serum HBV DNA levels are associated with high risks of hepatocellular carcinoma (HCC) and cirrhosis in patients with chronic hepatitis B (CHB). Although the immune-tolerant (IT) phase ...
gut.bmj

The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications

4 Department of Hepatogastroenterology, Hopital Claude Huriez, CHRU Lille, France Correspondence to: Professor J-F Colombel Department of Hepato-Gastroenterology, Hopital Claude Huriez, CHRU de Lille, ...
gut.bmj

Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-

Dr S N Andersen; Institute of Forensic Medicine, The National Hospital, N-0027 Oslo, Norway. BACKGROUND K-rasmutation is one of the first genetic alterations in classical colorectal carcinogenesis.