snmjournals.org

Somatostatin Receptor Imaging and Theranostics: Current Practice and Future Prospects

A new era of precision diagnostics and therapy for patients with neuroendocrine neoplasms began with the approval of somatostatin receptor (SSTR) radiopharmaceuticals for PET imaging followed by ...
snmjournals.org

Head-to-Head Comparison of mpMRI, PSMA, GRPR PET/CT, and PET/CT Plus MRI for Local Staging of Primary Prostate Cancer and Their Prognostic Value

Journal of Nuclear Medicine January 2026, jnumed.125.271410; DOI: https://doi.org/10.2967/jnumed.125.271410 ...
snmjournals.org

Rational Linker Design to Accelerate Excretion and Reduce Background Uptake of Peptidomimetic PSMA-Targeting Hybrid Molecules

The evolution of peptidomimetic hybrid molecules for preoperative imaging and guided surgery targeting the prostate-specific membrane antigen (PSMA) significantly progressed over the past few years, ...
snmjournals.org

Current Landscape in Clinical Pretargeted Radioimmunoimaging and Therapy

The principle of pretargeted radioimmunoimaging and therapy has been investigated over the past 30 y in preclinical and clinical settings with the aim of reducing the radiation burden of healthy ...
snmjournals.org

Discovery of 18 F-JK-PSMA-7, a PET Probe for the Detection of Small PSMA-Positive Lesions

Prostate-specific membrane antigen (PSMA), expressed by most prostate carcinomas (PCa), is a promising target for PCa imaging. The application of PSMA-specific 18F-labeled PET probes such as ...
snmjournals.org

Nanoparticle Diagnostics and Theranostics in the Clinic

Nanoparticles possess unique features that may be useful for disease diagnosis and therapy. Preclinically, many different nanodiagnostics have been explored, but only a few have made it to the market.
snmjournals.org

Denoising of Scintillation Camera Images Using a Deep Convolutional Neural Network: A Monte Carlo Simulation Approach

Scintillation camera images contain a large amount of Poisson noise. We have investigated whether noise can be removed in whole-body bone scans using convolutional neural networks (CNNs) trained with ...
snmjournals.org

Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy

Radiolabeled fibroblast activation protein (FAP) inhibitors (FAPIs) have shown promise as cancer diagnostic agents; however, the relatively short tumor retention of FAPIs may limit their application ...
snmjournals.org

Real-World Comparison of Cabazitaxel Versus

Journal of Nuclear Medicine November 2024, jnumed.124.268807; DOI: https://doi.org/10.2967/jnumed.124.268807 ...
snmjournals.org

Practical PET Respiratory Motion Correction in Clinical PET/MR

Respiratory motion during PET acquisition may lead to blurring in resulting images and errors in quantification (1,2). Areas in the upper abdomen and thorax are particularly adversely affected. In the ...
snmjournals.org

Head-to-Head Prospective Comparison of Quantitative Lung Scintigraphy and Segment Counting in Predicting Pulmonary Function in Lung Cancer Patients Undergoing Video-Assisted ...

Lung cancer is the most common cause of death among oncologic patients worldwide (1). Resection is the treatment of choice for early-stage non–small cell lung cancer (2). Because of a common risk ...
snmjournals.org

Translocator Protein 18 kDa–Targeted Total-Body PET Imaging Reveals Immune-Specific Vascular Inflammation in Large-Vessel Vasculitis: A Prospective Head-to-Head Comparison with

Journal of Nuclear Medicine December 2025, jnumed.125.270910; DOI: https://doi.org/10.2967/jnumed.125.270910 ...