The 49ers face injury concerns as Mac Jones targets Week 1 return as Brock Purdy’s reliable backup quarterback option.

San Francisco quarterback Mac Jones sustained a knee sprain in the 49ers’ second preseason game on Saturday and won’t be available when the NFL team closes its preseason schedule on Saturday.

Here's who stood out on Day 16 of 49ers training camp. Keep in mind, Mac Jones sprained his knee in the 49ers' preseason win over the Raiders on Saturday.

Back in Tuscaloosa, the Crimson Tide received some troubling news about one of last year's starters. Running back Jam Miller is going to miss time with an upper-body injury. Miller finished second on Alabama in rushing yards last season with 668 behind quarterback Jalen Milroe (726).

Before Los Angeles Chargers backup quarterback Trey Lance became one of the standout players of the ongoing preseason, he failed to cement himself as a long-term option for the San Francisco 49ers

San Francisco 49ers head coach Kyle Shanahan provided several injury updates following Saturday's preseason victory over the Las Vegas Raiders at Allegiant Stadium. Right guard Dominick Puni left the game during the starters' lone drive and did not return. "Dominick Puni left...

Kyle Shanahan shared an update on Mac Jones after the San Francisco 49ers quarterback sustained a knee injury against the Las Vegas Raiders.

The San Francisco 49ers have seen changes in their injury list as some key players return while others remain sidelined.