The FDA has begun soliciting feedback to inform the next version of the Prescription Drug User Fee Act. User fees remain ...

A 28-year-old woman was admitted to the hospital because of severe hypoxemia and right heart failure that had been caused by ...

A small-molecule drug proves its mettle in the treatment of spinal muscular atrophy, a disease amenable to intervention at the pre-mRNA level.

Though infant mortality has continuously been targeted by health policy agendas, policies tend to place it in an individualistic and narrow frame, failing to consider and address its structural ...

The author describes the scientific foundations of a clinical trial of a first-in-class small-molecule estrogen receptor degrader to treat patients with metastatic breast cancer.

Understanding today’s corporatization of U.S. health care requires seeing it from a historical perspective, as a process that began with a change in the business model of care delivery in the 1920s.

To prevent the spread of inaccurate information, academic and health care institutions will need to equip scientists and clinicians to engage effectively on nontraditional media platforms.

In 15 patients with primary aldosteronism, baxdrostat (a second-generation, nonimidazole aldosterone synthase inhibitor) resolved or reduced the severity of hypertension, excessive aldosterone ...

During 2018–2024, the percentage of N. gonorrhoeae isolates carrying tetM, which confers tetracycline resistance, increased from less than 10% to more than 30% across the United States.

In 2006, a prospective observational study first showed that physical activity after a colon cancer diagnosis was linked to a decreased risk of recurrence and death.1 Since then, numerous observati ...

A 59-year-old man presented with a 5-hour history of severe, pleuritic chest pain after vomiting. CT of the chest revealed air in the mediastinum extending up to the neck and perforation of the eso ...

Myasthenia gravis, an immune-mediated neurologic disorder, has for the past century been treated effectively with various immunotherapies, ranging from thymectomy to approved targeted agents.1,2 Th ...