Nerve fibers are surrounded by a myelin sheath. Scientists at the Technical University of Munich (TUM) have now made the first-ever "live" observations of how this protective layer is formed. The team ...

Researchers have demonstrated that enhancing myelin renewal in the brains of transgenic APP/PS1 mouse models of Alzheimer's disease (AD) can improve their task-related hippocampal activity. "To the ...

Laura holds a Master's in Experimental Neuroscience and a Bachelor's in Biology from Imperial College London. Her areas of expertise include health, medicine, psychology, and neuroscience. Laura holds ...

As the brain ages, the insulating myelin sheath around axons begins to degrade. Could this white-matter degeneration trigger Alzheimer’s disease? In a preprint on bioRxiv, researchers led by Constanze ...

The study covered in this summary was published in medRxiv.org as a preprint and has not yet been peer reviewed. Tau protein levels are lower in more highly myelinated cortical regions. Tau spreading ...

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration. Using transcriptomic profiling, the ...

The disruption of axons—the thread-like part of nerve cells that transmits electrical signals—is associated with Alzheimer's disease. One way axonal function may be hindered is through damage to the ...

New production or recycling of cholesterol: The duration of the disorder makes all the difference. The degradation and regeneration of myelin sheaths characterise neurological disorders such as ...

Myelin, a sheath of insulation around nerves that enables electrical impulses to efficiently travel through the central nervous system, is diminished in mice that have a gene deletion associated with ...