Amylin functions as part of the endocrine pancreas and contributes to glycemic control. The peptide is secreted from the pancreatic islets into the blood circulation and is cleared by peptidases in the kidney.

May 13, 2025 · Amylin is a peptide hormone involved in satiation. Amylin mimetics have potential as therapies for obesity and diabetes mellitus, but clinical development has proven challenging.

Amylin, an anorexic neuroendocrine hormone co-secreted with insulin, is deficient in individuals with diabetes and plays an important role in postprandial glucose homeostasis, with additional potential …

Aug 19, 2025 · Amylin, a hormone that controls appetite and blood sugar by activating three different receptors in the brain, could be the basis for the next blockbuster obesity drugs.

Jul 19, 2025 · Amylin is a neuroendocrine hormone produced and released by the pancreatic beta cells, the same cells that produce insulin. Its release into the bloodstream occurs in response to food …

Nov 23, 2024 · Amylin is a 37-amino-acid, neuroendocrine peptide hormone co-secreted with insulin by pancreatic beta-cells in response to nutrient intake. Though it has a short half-life, amylin is a …

Mar 12, 2025 · Development of Novel Amylin Analogs: Researchers have developed numerous novel amylin analogs with improved stability, pharmacokinetics, and tolerability. These analogs are being …

By targeting specific neurons in the hindbrain and the hypothalamus, and through subsequent downstream signalling in additional brain regions, amylin has the potential to increase satiety and …

Aug 19, 2025 · Amylin, a hormone that controls appetite and blood sugar by activating three different receptors in the brain, could be the basis for the next blockbuster obesity drugs.

Amylin acts as a natural satiety signal that suppresses appetite, delays gastric emptying and reduces food intake by activating specific amylin receptors present in many regions of the brain.