In pathology, extranodal extension (ENE) refers to the spread of tumour cells beyond the lymph node capsule into the surrounding tissues.

Jul 28, 2025 · Extranodal extension (ENE) describes when cancer cells, having spread to a lymph node, grow beyond its outer covering (the capsule) and invade surrounding tissues. This indicates a …

Extranodal extension (ENE) is defined as the tumor cells breaking through the lymph node capsule into peripheral adipose tissue and causing connective tissue reaction (Fig. 1 A,B).

Extranodal extension is the growth of nodal metastatic disease beyond the capsule of the specific lymph node.

Sep 20, 2023 · Extranodal extension (ENE) is a pattern of cancer growth from within the lymph node (LN) outward into perinodal tissues, critically defined by disruption and penetration of the tumor …

Nov 21, 2025 · Extranodal extension is the process where the growing cluster of malignant cells infiltrates and then penetrates the full thickness of the lymph node capsule. Once breached, the …

Jan 13, 2020 · Extranodal extension refers to the growth of a nodal cancer metastasis beyond the confines of the capsule of a lymph node into adjacent tissues. Less preferred synonyms include …