The mobile phase, or the liquid phase that runs across the column during separation, for HILIC is typically composed of a high amount of water-miscible, polar organic solvent and a low amount of …

Hydrophilic interaction chromatography (HILIC) columns separate polar to highly polar compounds that would be poorly retained in traditional reversed-phase liquid chromatography (LC) separations.

An introduction to the HILIC separation technique and an overview of the strategies for developing robust methods for separation of polar and hydrophilic compounds.

Thermo Scientific Hydrophilic Interaction Liquid Chromatography (HILIC) columns provide strong retention of polar hydrophilic compounds that are unretained under conventional reversed phase …

Aug 2, 2025 · HILIC’s primary purpose is to enable their accurate identification and quantification. Many standard chromatography techniques, such as reversed-phase liquid chromatography, struggle with …

Explore high-performance HILIC columns from Phenomenex for precise chromatography and improved retention of polar analytes. Explore advanced solutions for hydrophilic interaction chromatography.

Hydrophilic interaction chromatography (HILIC) is a powerful chromatographic technique for separating polar compounds. It offers a unique selectivity compared to reversed-phase chromatography, making …

InfinityLab Poroshell HILIC-Z – Zwitterionic chemistry with a proprietary bonding technique that offers powerful separation, stability across wide a wide pH range, and excellent peak shape

HILIC enables retention of hydrophilic compounds that are difficult to retain by reversed phase liquid chromatography (RPLC). You can also achieve better separation efficiency than RPLC for very polar …

The ZIC ® -HILIC Column is designed to retain and separate all types of polar and hydrophilic compounds and for robust chromatography with high selectivity and reproducibility.