The ins and outs of serine and glycine metabolism in cancer
Jan 28, 2021 · Geeraerts et al. explore the centrality of serine and glycine metabolism to cancer survival, and how targeting the de novo serine and glycine synthesis pathways can complement current …
Serine and one-carbon metabolism in cancer - Nature
Sep 16, 2016 · Serine supports many biosynthetic pathways, including the one-carbon cycle. This Review discusses how cancer cells acquire and use serine, and explores novel therapeutic …
Serine Protease, Enzyme Catalysis | Learn Science at Scitable
Aug 24, 2010 · The first serine protease scientists explored in detail was chymotrypsin, a digestive enzyme synthesized in our pancreas, along with the related enzymes trypsin and elastase.
Functional profiling of serine, threonine and tyrosine sites
Sep 23, 2024 · The use of an adenine base editor enables identification of functional serine, threonine and tyrosine residues that impact cell fitness on a genome-wide scale with possible involvement in ...
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and
May 6, 2025 · Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis …
Species-specific serine metabolism differentially controls natural ...
Aug 14, 2025 · Serine metabolism was enhanced by cytokine activation in both species, but functional profiling indicated that activated human and mouse NK cells differed in their utilization of serine to …
An epidermal serine sensing system for skin healthcare - Nature
Mar 18, 2025 · Serine is an important biomarker for skin healthcare. Here, the authors introduce a portable epidermal sensing system capable of direct sampling and in situ quantification of serine on …
Limiting serine availability during tumor progression promotes muscle ...
Dec 21, 2024 · Here, we demonstrate that decreased serine availability during tumor progression promotes myotubes diameter reduction in vitro and induces muscle wasting in in vivo mice models.
Cellular redox state constrains serine synthesis and ... - Nature
Sep 16, 2019 · The de novo serine synthesis pathway is upregulated in many cancers. However, even cancer cells with increased serine synthesis take up large amounts of serine from the environment 1, …
Impaired glycolysis-derived serine metabolism as a key driver of ...
Dec 4, 2025 · Previous studies showed inhibition of glycolytic enzyme pyruvate kinase M2 disrupts podocyte function. The study shows that PGK1-serine axis regulates and drives aging and damage …